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Báo cáo y học: "The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2). | Open Access The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3 2 Andrew Hesketh Wenqiong Joan Chen A Jamie Ryding Sherman Change and Mervyn Bibb Addresses Department of Molecular Microbiology John Innes Centre Norwich Research Park Colney Norwich NR4 7UH UK. tVerenium Corporation San Diego CA 92121 USA. Biology Department San Diego State University San Diego CA 92182 USA. Dermtech International San Diego CA 92121 USA. Correspondence Andrew Hesketh. Email andrew.hesketh@bbsrc.ac.uk Published 3 August 2007 Genome Biology 2007 8 R.161 doi l0.ll86 gb-2007-8-8-rl 61 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 8 R161 Received 14 May 2007 Revised ll June 2007 Accepted 3 August 2007 2007 Hesketh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Regulation of production of the translational apparatus via the stringent factor ppGpp in response to amino acid starvation is conserved in many bacteria. However in addition to this core function it is clear that ppGpp also exhibits genus-specific regulatory effects. In this study we used Affymetrix GeneChips to more fully characterize the regulatory influence of ppGpp synthesis on the biology of Streptomyces coelicolor A3 2 with emphasis on the control of antibiotic biosynthesis and morphological differentiation. Results Induction of ppGpp synthesis repressed transcription of the major sigma factor hrdB genes with functions associated with active growth and six of the thirteen conservons present in the S. coelicolor genome. Genes induced following ppGpp synthesis included the alternative sigma factor SCO4005 many for .