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Báo cáo khoa học: "Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters: evidence for flexibility at its N-terminus"

vComparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters: evidence for flexibility at its N-terminus | Virology Journal BioMed Central Research Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters evidence for flexibility at its N-terminus Yang Su1 2 Gang Deng1 2 Yuanming Gai1 2 Yue Li1 2 Yang Gao1 2 Jiansen Du1 2 Yunqi Geng1 2 Qimin Chen1 2 and Wentao Qiao 1 2 Open Access Address 1Key Laboratory of Molecular Microbiology and Biotechnology Ministry of Education College of Life Sciences Nankai University Tianjin 300071 China and 2Key Laboratory of Microbial Functional Genomics Tianjin College of Life Sciences Nankai University Tianjin 300071 China Email Yang Su - tenlions@mail.nankai.edu.cn Gang Deng - foolduck@mail.nankai.edu.cn Yuanming Gai - sangny1234@yahoo.com.cn Yue Li - liyue_pg@yahoo.com.cn Yang Gao - gaoyang875@mail.nankai.edu.cn Jiansen Du - djs916@mail.nankai.edu.cn Yunqi Geng - gengyq@nankai.edu.cn Qimin Chen - qmchen@nankai.edu.cn Wentao Qiao - wentaoqiao@nankai.edu.cn Corresponding author Published 28 October 2009 Received 20 September 2009 Accepted 28 October 2009 Virology Journal 2009 6 179 doi 10.ll86 1743-422X-6-179 This article is available from http www.virologyj.com content 6 1 179 2009 Su et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Jembrana disease virus JDV encodes a potent regulatory protein Tat that strongly stimulates viral expression by transactivating the long terminal repeat LTR promoter. JDV Tat jTat promotes the transcription from its own LTR as well as non-cognate LTRs by recruiting host transcription factors and facilitating transcriptional elongation. Here we compared the sequence requirements of jTat for transactivation