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Báo cáo khoa học: " Evolutionary and structural analyses of alpha-papillomavirus capsid proteins yields novel insights into L2 structure and interaction with L1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evolutionary and structural analyses of alpha-papillomavirus capsid proteins yields novel insights into L2 structure and interaction with L1 | Virology Journal BioMed Central Research Evolutionary and structural analyses of alpha-papillomavirus capsid proteins yields novel insights into L2 structure and interaction with Open Access John Lowe1 Debasis Panda2 Suzanne Rose1 Ty Jensen1 Willie A Hughes1 For Yue Tso1 and Peter C Angeletti 1 Address 1School of Biological Sciences Nebraska Center for Virology University of Nebraska-Lincoln Lincoln NE 68583-0900 USA and Veterinary Biomedical Sciences Nebraska Center for Virology University of Nebraska-Lincoln Lincoln NE 68583-0900 USA Email John Lowe - johnmartinlowe@gmail.com Debasis Panda - debasisvet@gmail.com Suzanne Rose - suzannerose@alltel.net Ty Jensen - tjensen8@neb.rr.com Willie A Hughes - boyboy32720@yahoo.com For Yue Tso - keyucao@bigred.unl.edu Peter C Angeletti - Pangeletti2@unl.edu Corresponding author Published 17 December 2008 Virology Journal 2008 5 150 doi l0.ll86 l743-422X-5-l50 Received 30 August 2008 Accepted l7 December 2008 This article is available from http www.virologyj.Com content 5 l l50 2008 Lowe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background PVs PV are small non-enveloped double-stranded DNA viruses that have been identified as the primary etiological agent for cervical cancer and their potential for malignant transformation in mucosal tissue has a large impact on public health. The PV family Papillomaviridae is organized into multiple genus based on sequential parsimony host range tissue tropism and histology. We focused this analysis on the late gene products major Ll and minor L2 capsid proteins from the family Papillomaviridae genus Alpha-papillomavirus. Alpha-PVs preferentially infect oral and anogenital mucosa of humans and primates with varied risk of .