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Báo cáo khoa học: "A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement"

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement | Virology Journal BioMed Central Open Access Hypothesis A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement YuanyongXu11 Chuanfu Zhang11 Leili Jia11 Cuirong Wen2 Huihui Liu3 Yong Wang1 Yansong Sun1 Liuyu Huang1 Yusen Zhou 4 and Hongbin Song 1 Address institute of Disease Control and Prevention Academy of Military Medical Science Beijing 100071 PR China 2302 Hospital of People s Liberation Army Beijing 100039 PR China 3Chinese Center for Disease Control and Prevention Department of Epidemiology Beijing 100050 PR China and 4State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 PR China Email YuanyongXu - xyy_827@sina.com Chuanfu Zhang - hnzcf@126.com Leili Jia - jialeili@163.com Cuirong Wen - wen_cuirong@126.com Huihui Liu - liuhuihui323@sina.com Yong Wang - ywang7508@yahoo.com.cn Yansong Sun - sunys1964@hotmail.com Liuyu Huang - huangly@nic.bmi.ac.cn Yusen Zhou - yszhou@nic.bmi.ac.cn Hongbin Song - hongbinsong@263.net Corresponding authors fEqual contributors Published 12 August 2009 Virology Journal 2009 6 123 doi 10.1186 I743-422X-6-I23 Received 1 June 2009 Accepted 12 August 2009 This article is available from http www.virologyj.eom content 6 1 123 2009 Xu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The complement system is one of the most potent weapons of innate immunity. It is not only a mechanism for direct protection against invading pathogens but it also interacts with the adaptive immunity to optimize the pathogen-specific humoral and cellular defense cascades in the body. Complement-mediated lysis of HIV is inefficient but the presence of HIV particles results in .

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