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Colorectal Cancer: Six Years of Research Progress

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It is hard to find adrenal carcinomas early and they are often quite large when diagnosed. Adrenal carcinomas are often found earlier in children than in adults because adrenal cancers in children more commonly secrete hormones. Children will show outward signs of excess hormone production early. For example they may develop very early signs of puberty due to the sex hormones that sometimes are produced by adrenal cancer. In adults, these tumors may be found early by accident, when a CT scan is done for some other health concern. The American Cancer Society has official recommendations for the early detection. | Colorectal Cancer Six Years of Research Progress March 2008 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Colorectal Cancer Six Years of Research Progress Table of Contents Highlights of NCI s Recent Progress in Colorectal Cancer.III T he Colorectal Cancer Burden.1 NCI Planning for Colorectal Cancer Research.5 NCI s Investment in Colorectal Cancer Research.7 NCI Funding for Colorectal Cancer Research.7 Research Projects.9 Clinical Trials.11 Specialized Programs of Research Excellence.12 Publications.13 NCI s Progress in Colorectal Cancer Research.14 Biology.14 Research Projects.14 Initiatives.15 Research Highlights.17 Etiology.19 Research Projects.19 Clinical Trials.21 Initiatives.22 Research Highlights.23 Prevention.25 Research Projects.25 Clinical Trials.26 Initiatives.27 Research Highlights.29 Early Detection and Diagnosis.31 Research Projects.31 Clinical Trials.32 Initiatives.33 Research Highlights.35 Treatment and Prognosis.37 Research Projects.37 Clinical Trials.39 Initiatives.40 Research Highlights.42 Cancer Control Survivorship and Outcomes.44 Research Projects.44 Clinical Trials.46 Initiatives.47 Research Highlights.49 1 List of Figures Figure 1. Colorectal Cancer Estimated New Cases and Deaths by Year 1999 to 2008.1 Figure 2. Colorectal Cancer Incidence Rate Trends by Racial Ethnic Group 1984 to 2004.2 Figure 3. Colorectal Cancer Male-Female Incidence Rate Trends 1984 to 2004.2 Figure 4. Colorectal Cancer Mortality Rate Trends All Races 1984 to 2004.3 Figure 5. Colorectal Cancer Male-Female Mortality Rate Trends 1984 to 2004.3 Figure 6. Trends in Colorectal Cancer Screening FOBT and Endoscopy 1987 to 2005.4 Figure 7. Trends in NCI Funding for Colorectal Cancer Research FY2000 to FY2006.7 Figure 8. Estimated Funding for Extramural Research by Scientific Area FY2000 to FY2006 .8 Figure 9. Total Number of NCI-Sponsored Research Projects Relevant to Colorectal Cancer FY2000 to fY2006.9 Figure 10. Colorectal Cancer Research by PRG

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