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ABSORPTION AND DRUG DEVELOPMENT

This book is written for the practicing pharmaceutical scientist involved in absorption–distribution–metabolism–excretion (ADME) measurements who needs to communicate with medicinal chemists persuasively, so that newly synthesized molecules will be more ‘‘drug-like.’’ ADME is all about ‘‘a day in the life of a drug molecule’’ (absorption, distribution, metabolism, and excretion). Specifically, this book attempts to describe the state of the art in measurement of ionization constants (pKa), oil–water partition coefficients (log P/log D), solubility, and permeability (artificial phospholipid membrane barriers). Permeability is covered in considerable detail, based on a newly developed methodology known as parallel artificial membrane permeability assay (PAMPA) | ABSORPTION AND DRUG DEVELOPMENT ABSORPTION AND DRUG DEVELOPMENT Solubility Permeability and Charge State ALEX AVDEEF pION Inc. WI LEY- INTERSCIENCE AJOHN WILEY SONS INC. PUBLICATION Copyright 2003 by John Wiley Sons Inc. All rights reserved. Published by John Wiley Sons Inc. Hoboken New Jersey. Published simultaneously in Canada. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photocopying recording scanning or otherwise except as permitted under Section 107 or 108 of the 1976 United States Copyright Act without either the prior written permission of the Publisher or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center Inc. 222 Rosewood Drive Danvers MA 01923 978-750-8400 fax 978-750-4470 or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department John Wiley Sons Inc. 111 River Street Hoboken NJ 07030 201 748-6011 fax 201 748-6008 e-mail permreq@wiley.com. Limit of Liability Disclaimer of Warranty While the publisher and author have used their best efforts in preparing this book they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages including but not limited to special incidental consequential or other damages. For general information on our other products and services please contact our Customer Care Department within the U.S. at 877-762-2974 outside the U.S. at .