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Báo cáo y học: "Diabetes and sepsis outcomes – it is not all bad news"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Diabetes and sepsis outcomes – it is not all bad news. | Available online http ccforum.eom content 13 1 117 Commentary Diabetes and sepsis outcomes - it is not all bad news Sachin Yende1 2 and Tom van der Poll3 1The Clinical Research Investigation and Systems Modeling of Acute Illness CRISMA Laboratory University of Pittsburgh Pittsburgh PA 15261 USA 2Department of Critical Care Medicine University of Pittsburgh Pittsburgh PA 15261 USA 3Center of Infection and Immunity Amsterdam CINIMA and Center for Experimental and Molecular Medicine Academic Medical Center University of Amsterdam 1105 AZ Amsterdam The Netherlands Corresponding author Sachin Yende yendes@upmc.edu Published 18 February 2009 This article is online at http ccforum.com content 13 1 117 2009 BioMed Central Ltd Critical Care 2009 13 117 doi 10.1186 cc7707 See related research by Esper et al. http ccforum.com content 13 1 R18 Abstract Patients with diabetes mellitus have an increased risk of developing infections and sepsis. In this issue of Critical Care Esper and colleagues report on a large survey involving 12.5 million sepsis cases that examined the impact of pre-existing diabetes on organ dysfunction during sepsis. Their main conclusion was that diabetes patients relative to non-diabetics were less likely to develop respiratory failure and more likely to develop renal failure during the course of sepsis. Most physicians recollect cases where patients with diabetes had trivial injuries or infection but rapidly progressed to life threatening sepsis and death. Although such clinical experiences may suggest that diabetes is associated with more severe infections and poor outcomes observational studies have shown conflicting results. The interaction between diabetes a chronic condition and an acute infection is complex. Most studies suggest that diabetes increases susceptibility to infection. However its effect on outcomes of infection especially in the critical care setting is less clear. In this issue of Critical Care Esper and colleagues 1 have added to .