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Báo cáo y học: "A mathematical model of quorum sensing regulated EPS production in biofilm communities"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A mathematical model of quorum sensing regulated EPS production in biofilm communities. | Frederick et al. Theoretical Biology and Medical Modelling 2011 8 8 http www.tbiomed.eom content 8 1 8 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access A mathematical model of quorum sensing regulated EPS production in biofilm communities Mallory R Frederick1 Christina Kuttler2 Burkhard A Hense3 and Hermann J Eberl1 Correspondence mfrederi@uoguelph.ca heberl@uoguelph.ca department of Mathematics and Statistics University of Guelph 50 Stone Rd E Guelph ON Canada N1G 2W1 Full list of author information is available at the end of the article 2 BioMed Central Abstract Background Biofilms are microbial communities encased in a layer of extracellular polymeric substances EPS . The EPS matrix provides several functional purposes for the biofilm such as protecting bacteria from environmental stresses and providing mechanical stability. Quorum sensing is a cell-cell communication mechanism used by several bacterial taxa to coordinate gene expression and behaviour in groups based on population densities. Model We mathematically model quorum sensing and EPS production in a growing biofilm under various environmental conditions to study how a developing biofilm impacts quorum sensing and conversely how a biofilm is affected by quorum sensing-regulated EPS production. We investigate circumstances when using quorum-sensing regulated EPS production is a beneficial strategy for biofilm cells. Results We find that biofilms that use quorum sensing to induce increased EPS production do not obtain the high cell populations of low-EPS producers but can rapidly increase their volume to parallel high-EPS producers. Quorum sensing-induced EPS production allows a biofilm to switch behaviours from a colonization mode with an optimized growth rate to a protection mode. Conclusions A biofilm will benefit from using quorum sensing-induced EPS production if bacteria cells have the objective of acquiring a thick protective layer of EPS or if they wish to clog their environment with