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Báo cáo y học: "Novel concepts in virally induced asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Novel concepts in virally induced asthma. | Clinical and Molecular Allergy BioMed Central Review Novel concepts in virally induced asthma Matthew M Huckabee and R Stokes Peebles Jr Open Access Address Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University School of Medicine Nashville TN 37232-2650 USA Email Matthew M Huckabee - matthew.m.huckabee@vanderbilt.edu R Stokes Peebles - stokes.peebles@vanderbilt.edu Corresponding author Published 20 January 2009 Received 19 December 2008 Accepted 20 January 2009 Clinical and Molecular Allergy 2009 7 2 doi l0.ll86 l476-796l-7-2 This article is available from http www.clinicalmolecularallergy.cOm content 7 l 2 2009 Huckabee and Peebles licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition recent evidence strongly suggests that viral infections may also have a causal role in the development of childhood asthma. In this article we will briefly describe the general perception of how the link between infections and asthma has changed over the last century and then focus on very recent developments that have provided new insights into the contribution of viruses to asthma pathogenesis. Highlighted areas include the contribution of severe early life viral infections to asthma inception genetic determinants of severe viral infections in infancy the differences in innate and adaptive immune system cytokine responses to viral infection between asthmatic and nonasthmatic subjects and a potential vaccine strategy to prevent severe early life virally-induced illness. Background Infections have been recognized to be a cause of asthma exacerbations for over 100 years. In his landmark .