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Báo cáo y học: "Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. | BioMed Central Comparative Hepatology Review Open Access Structural and functional aspects of liver sinusoidal endothelial cell fenestrae a review Filip Braet and Eddie Wisse Address Laboratory for Cell Biology and Histology Free University of Brussels VUB Laarbeeklaan 103 1090 Brussels-Jette Belgium E-mail Filip Braet - filipbra@cyto.vub.ac.be Eddie Wisse - wisse@cyto.vub.ac.be Corresponding author Published 23 August 2002 Received 6 August 2002 Accepted 23 August 2002 Comparative Hepatology 2002 1 1 This article is available from http www.comparative-hepatology.cOm content 1 1 1 2002 Braet and Wisse licensee BioMed Central Ltd. This article is published in Open Access verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae regarding their structure origin species specificity dynamics and formation will be explored. In addition the role of liver sinusoidal endothelial fenestrae in relation to lipoprotein metabolism fibrosis and cancer will be approached. Introduction Liver sinusoidal endothelial cells LSEC constitute the sinusoidal wall also called the endothelium or endothelial lining. The liver sinusoids can be regarded as unique capillaries which differ from other capillaries in the body because of the presence of open pores or fenestrae lacking a diaphragm and a basal lamina underneath the endothelium. The first description and electron microscopic observation of LSEC fenestrae was given by Wisse in 1970 1 . The application of perfusion fixation to the rat liver revealed groups of fenestrae arranged in sieve plates. In subsequent reports Widmann 2 and Ogawa 3 verified the existence of fenestrae in LSEC by using .