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Pharmaceutical Substances Syntheses, Patents, Applications - Part 161

Pharmaceutical Substances Syntheses, Patents, Applications - Part 161. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Perlapine P 1601 OH n 02h5 3 S DCC n n v bn JL v --------------------------------------------- v 1 - hydroxybenzotriazole V 1. H2 Pd-C ch3 2. H2n4-CH3 ch3 ------------- o chA 0 Xl-NHnX CH3 Xr ch3 CH3 H2N CH3 CHj Perindopril erbumine Referencef s Vincent M. et al. Tetrahedron Lett. TELEAY 23 1677 1982 . US 4 508 729 ADIR . EP 49 658 ADIR appl. 29.9.1981 F-prior. 2.10.1980 7.4.1981 . industrial process US4914 214 ADIR 3.4.1990 F-prior. 17.9.1987 . Formulation s tabl. 2 mg 4 mg 8 mg Trade Name s D Coversum Cor Servier I Coversyl Servier USA Aceon Rhöne-Poulenc F Coversyl Servier Procaptan Stroder Rorer GB Coversyl Servier Perlapine ATC N05C Use hypnotic RN 1977-11-3 MF C19H21N3 MW 291.40 LDS0 61 mg kg M i.v. 270 mg kg M p.o. 60 mg kg R i.v. 660 mg kg R p.o. CN 6- 4-methyl-l-piperazinyl -l I -dibcnz e azcpinc 2-aminodiphenyl-methane 0 JI CI- TI toluene -------- aici3 1 2-dichlarobenzene phosgene 2-isocyanatodi-phenyl methane 1602 P Perphenazine 6-oxo - 5 6-dihydro-1 1 H-dibenz b e ozepine I P0CI3 ch3 2n-c6h5 -------------- 6-chloro-11 H-di-benz b e azepine h3c 1 -methylpiperazine Reference s US 3 389 139 Dr. A. Wander 18.6.1968 prior. 10.6.1964 2.6.1966 . Formulation s tabl. 2.5 mg Trade Name s J Hypnodin Takeda Perphenazine ATC N05AB03 Use neuroleptic anti-emetic RN 58-39-9 MF C2IH26C1N3OS MW 403.98 EINECS 200-381-5 LD5o 19 mg kg M i.v. 120 mg kg M p.o. 34 mg kg R i.v. 318 mg kg R p.o. 51 mg kg dog i.v. CN 4- 3- 2-chloro-10 7-phenothiazin-10-yl propyl -1 -piperazineethanol 2-chloro-10- 3-chloro-propyl phenothiozine 1 2-chlorophenothiozine 1 -bromo-3-chloropropane 1 - 2-hydroxyethyl -piperazine Reference s US 2 838 507 Searle 1958 appl. 1957 prior. 1955 . carbamate derivatives US 2 860 138 Schering Corp. 1958 appl. 1956 . acetate US 2 766 235 J. W. Cusic 1956 appl. 1956 . Formulâtion s amp. 76 mg ml drops 4 mg ml inj. flask 1000 mg tabl. 2 mg 4 mg 8mg 16 mg Peruvosidc P 1603 Trade Name s D Decentan Merck I F Trilifan Retard Schering- Plough GB Fentazin Goldshield J .