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Pharmaceutical Substances Syntheses, Patents, Applications - Part 156

Pharmaceutical Substances Syntheses, Patents, Applications - Part 156. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pamidronic acid p 1551 Trade Name s D Taxol Bristol-Myers Squibb F Taxol Bristol-Myers Squibb GB Taxol Bristol-Myers Squibb I Taxol Bristol-Myers Squibb J Taxol Bristol-Myers Squibb USA Taxol Bristol-Myers Squibb Pamidronic acid APD ATC MO5BAO3 Use calcium metabolism regulator treatment of Paget s disease hypercalcemia of malignancy RN 40391-99-9 MF C3HhNO7P2 MW 235.07 EINECS 254-905-2 CN 3-amino-l-hydroxypropylidene bis phosphonic acid disodium salt RN 57248-88-1 MF C3H9NNa2O7P2 MW 279.03 EINECS 260-647-1 u M -COOH h3po3 pci h2n 0 3 phosphorous trichloride 0-ominopropionic oc d phosphite H2N C00H I H-jPO-j POCIj or PCỊj H3PO4 PC13 Pomidrontc ocid ÇOjH2 H2N x OH POjH2 Pomidronic ocid Pomidronic acid Reference s a DOS 2 130 794 Benckiser appl. 22.6.1971 . b DOS 2 658 961 Benckiser appl. 24.12.1976 . DOS 2 943 498 Henkel appl. 27.10.1981 . c EP 82 472 Henkel appl. 15.12.1982 D-prior. 23.12.1981 . crystalline disodium salt JP 61 043 196 Ciba-Geigy appl. 6.8.1984 . controlled-release granule CA 2 024 631 Ciba-Geigy appl. 7.9.1989 . pharmaceutical formulation of disodium pamidronate or controlling calcium deposition and treatment of calcium metabolism disorders DOS 2 405 254 Henkel appl. 4.2.1974 . DOS 2 553 963 Henkel appl. 1.12.1975 . AT 538 311 Henkel appl. 2.1.1981 . 1552 P Pancuronium bromide topical pharmaceutical formulation EP 407 345 Ciba-Geigy Henkel appl. 28.6.1990 CH-prior. 7.7.1989 . synergistic combination with cytostatics DOS 3 804 686 Henkel DKFZ appl. 15.2.1988 . Formulation s amp. 15 mg 5 ml 30 mg 5 ml 60 mg 5 ml 90 mg 5 ml 15 mg 10 ml 30 mg 10 ml 60 mg 10 ml 90 mg 10 ml as disodium salt Trade Name sf GB Aredia Novartis 1989 J Aredia Ciba-Geigy I Aredia Novartis Farma USA Aredia Novartis Pancuronium bromide ATC M03AC01 Use ganglionic blocker anticonvulsant RN 15500-66-0 MF C35H60Br2N2O4 MW 732.68 EINECS 239-532-5 LD5 13 pg kg M i.v. 21.2 mg kg M p.o. 153 p.g kg R i.v. 202 mg kg R p.o. CN l r- 2ß 3a 5a 16ß 17ß -3 17-bis acetyloxy androstane-2 .