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Pharmaceutical Substances Syntheses, Patents, Applications - Part 152

Pharmaceutical Substances Syntheses, Patents, Applications - Part 152. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Oxandrolone O 1511 W. vj Reference s FR 1 579 495 R. Aries appl. 22.1.1968 . Formulation s tabl. lOOmg Trade Name s F Dinulcid Lab. I Pharmascience wfm Flogan ABC wfm Restid UCB wfm Oxandrolone ATC A14AA08 Use anabolic RN 53-39-4 MF C19H30O3 MW 306.45 EINECS 200-172-9 LD50 1832 mg kg M p.o. 10 g kg R p.o. CN 5a 17P -17-hydroxy-17-methyl-2-oxaandrostan-3-one Pb O CO-CH3 4 OsO4 ---------------------- lead tetraacetate osmium tetroxide 170-hydroxy-17a-methyl- I 3-oxo-1 -ondrostene NoBH4 sodium borohydride Reference s US 3 128 283 Searle 7.4.1964 MEX-prior. 10.5.1961 . Pappo R. Jung C.J. Tetrahedron Lett. TELEAY 1962 365. starting material Counsell R.E. et al. J. Org. Chem. JOCEAH 27 248 1962 . Formulation s tabl. 2.5 mg 1512 O Oxaprozin Trade Name s J Vasorome Kowa USA Oxandrin BioTechnology Oxaprozin ATC M01AE12 Use anti-inflammatory RN. 21256-18-8 MF C18H15NO3 MW 293.32 EINECS 244-296-1 LD 0 93 mg kg M i.v. 1210 mg kg M p.o. 82 mg kg R i.v. 4470 mg kg R p.o. 124 mg kg dog i.v. 2 g kg dog p.o. CN 4 5-diphenyl-2-oxazolepropanoic acid benzoin succinic CH3COONH4 ommonium ocetote onhydride Reference s DE 1 670 005 Wyeth prior. 17.11.1967 . US 3 578 671 Wyeth 11.5.1971 prior. 6.11.1967 . Brown K. et al. Nature London NATUAS 219 164 1968 . Formulation s f. c. tabl. 600 mg Trade Name s J Actirin Wyeth 1986 Alvo Taisho Seiyaku 1985 USA Daypro Searle Oxatomide atc R06AE06 Use antiallergic RN 60607-34-3 MF C27H30N4O MW 426.56 EINECS 262-320-9 LD50 25 mg kg M i.v. 9596 mg kg M p.o. 29 mg kg R i.v. 1410 mg kg R p.o. 2 g kg dog p.o. CN l- 3- 4- diphenylmethyl -l-piperazinyl propyl -l 3-dihydro-2H-benzimidazol-2-one 2-benz-imidozolone 1 -bromo-3-chloropropone 1 - 3-chloropropyl - 2-benzimidazolone I Oxazepam o 1513 1 -benzhydryl-piperazine No2C03 Reference s BE 852 405 Janssen appl. 14.3.1977 USA-prior. 21.12.1976 2.4.1976 . US 4 250 176 Janssen 10.2.1981 prior. 6.2.1978 . Formulation s susp. 2.6 mg ml tabl. 30 mg Trade Name s D Tinset Janssen-Cilag 1982 F Tinset Janssen-Cilag .