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Pharmaceutical Substances Syntheses, Patents, Applications - Part 149

Pharmaceutical Substances Syntheses, Patents, Applications - Part 149. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Oleandomycin O 1481 o-chloronitro-benzene H2Nx_S NC UOH ----------- lithium hydroxide 2- 2-nitroonilino - 5-methylthiophene- 3-corbonitrile I 2-omino-3-cyano- 5-methylthiophene SnCI2 HCI EtOH H2O I ----------------- tin Il chloride 1. N-methyl-piperazine 2. toluene DMSO 4 1 Reference s EP 454 436 Lilly appl. 30.10.1991 GB-prior. 25.4.1990 . EP 733 634 Lilly appl. 25.9.1996 USA-prior. 24.3.1995 . . US 5 229 382 Lilly 20.7.1993 GB-prior. 25.4.1990 . EP 733 367 Lilly Co. appl. 25.9.1996 . Chakrabati J.K. et al. J. Med. Chem. JMCMAR 23 878 884 1980 . Hagopian G.S. Meyers D.B. Markham J.K. Teratology TJADAB 35 2 Abst. P65 1987 . intermediates and process for preparing olanzapine EP 831 098 Eli Lilly appl. 22.9.1997 USA-prior. 23.9.1996 . pharmaceutical compositions US 5 919 485 Eli Lilly 6.7.1999 appl. 20.9.1996 USA-prior. 24.3.1995 . EP 830 864 Eli Lilly appl. 22.9.1997 USA-prior. 23.9.1996 . crystalline olanzapine EP 733 635 Eli Lilly appl. 22.3.1996 USA-prior. 24.3.1995 . Formulation s f. c. tabl. 2.5 mg 5 mg 7.5 mg 10 mg Trade Name s D ZYPREXA Lilly I Zyprexa Lilly GB Zyprexa Lilly 1996 . USA Zyprexa Lilly Oleandomycin Troleandomycin ATC J01FA05 Use antibiotic RN 3922-90-5 MF C35H61NO12 MW 687.87 EINECS 223-495-7 LD5 460 mg kg M i.v. 8200 mg kg M p.o. 440 mg kg R i.v. 6700 mg kg R p.o. CN 3R- 3R 5 6S 7R 8R ll 12R 137f 14S 15S -12- 2 6-dideoxy-3-O-methyl-a-L-araWno-hexopyranosyl oxy -6-hydroxy-5 7 8 ll 13 15-hexamethyl-14- 3 4 6-trideoxy-3- dimethylamino -P-D-xy o-hexopyranosy l oxy -1 9-dioxaspiro 2.13 hexadecane-4 10-dione phosphate 1 1 RN 7060-74-4 MF C3JH61NOI2 H3PO4 MW 785.86 EINECS 230-351-7 LD5I 400 mg kg M i.v. 4 g kg M p.o. 480 mg kg R i.v. 1482 O Olprinone hydrochloride From fermentation solutions of Streptomyces antibioticus. Reference s US 2 757 123 Pfizer 31.7.1956 prior. 1.6.1953 29.6.1955 . US 2 842 481 Pfizer 8.7.1958 prior. 12.3.1957 . Formuiation s cps. 250 mg tabl. 100 mg vial 500 mg as phosphate Trade Nameisi D Oleandocyn Pfizer wfm I F .