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Pharmaceutical Substances Syntheses, Patents, Applications - Part 145

Pharmaceutical Substances Syntheses, Patents, Applications - Part 145. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nilutamide N 1441 rCH3 hn ch3 POCI3 ----------- phosphorus oxychloride nicotinic diethylamine acid Reference s DRP351 085 Ciba 1920 . DRP 441 707 Ciba 1924 . Formulation s drg. 50 mg in comb as calcium thiocyanate powder 150 mg sol. 250 mg ml Trade Name s D Felsol Roland -comb. Zellaforte Plus Eurim Pharma -comb. F Coramine Ciba wfm GB Coramine Ciba wfm 1 Miocardina Croce Bianca wfm J Coramin Ciba-Geigy- Takeda USA Coramine Ciba wfm Nilutamide RU-23908 ATC G03H L02BB02 Use non-steroidal antiandrogen for treatment of prostatic carcinoma RN 63612-50-0 MF Cl2H10F N3O4 MW 317.22 LD50 200 mg kg M p.o. 195 mg kg R p.o. CN 5 5-dimethyl-3- 4-nitro-3- trifluoromethyl phenyl -2 4-imidazolidinedione y-trifluorometnyl-ocetanilide HNO3 H2SO4 ------------- no2 3- trtfluoromethyl- 4- nitroaniline U CI CI ----------- phosgene ch3 H3C j nh2 CN no2 1 - 3-trif luoromethyl- 4-nitrophenyl -4.4-dimethyl-5 imino-2-imidazolidinone 2-amino-2-cyonopropone 3- trifluoromethyl- 4- nitrophenyl isocyanate I Reference s DOS 2 649 925 Roussel-Uclaf appl. 29.10.1976 F-prior. 29.10.1975 . US 4 097 578 Roussel-Uclaf 28.6.1978 F-prior. 29.10.1975 . synthesis q 3-trifluorornethyl-4-nitropheny isocyanate Rouche H. Bull. Cl. Sci. Acad. R. Belg. BCSAAF 13 346 1927 . JP6 725 067 Japan Bureau of Ind. Techn. appl. 15.3.1966 . 1442 N Nilvadipine medical use for the treatment of hormone dependent cancer other than pmstatic cancer WO 8 803 404 Roussel-Uclaf appl. 3.11.1987 I-prior. 4.11.1986 . Formulation s tabl. 50 mg Trade Name s F Anandron Cassenne USA Nilandron HoechstMarion Roussel Nilvadipine FR-34235 Niprodipine ATC C08CA10 Use calcium antagonist antihypertensive antianginal RN 75530-68-6 MF C19H19N3O6 MW 385.38 LD5 I 9150 pg kg M i.v. 1300 mg kg M p.o. 9650 pg kg R i.v. 1560 mg kg R p.o. 3850 pg kg dog i.v. 510 mg kg dog p.o. CN 2-cyano-l 4-dihydro-6-methyl-4- 3-nitrophenyl -3 5-pyridinedicarboxylic acid 3-methyl 5- l-methylethyl ester 3-nitro- benzoldehyde CHjO isopropyl acetoocetote isopropyl 2- .