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Pharmaceutical Substances Syntheses, Patents, Applications - Part 130

Pharmaceutical Substances Syntheses, Patents, Applications - Part 130. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Methoxyflurane M 1291 Methoxyflurane ATC N01AB03 Use inhalation anesthetic RN 76-38-0 MF C3H4C12F2O MW 164.97 EINECS 200-956-0 LD 0 150 mg kg M Í.V. 3600 mg kg R p.o. CN 2 2-dichloro-1 1 -difluoro-1 -methoxyethane F KOH CI C- F 1 1 -difluoro- 2 2 2-trichloro- ethone H3C OH KOH --------- Methoxyflurane 1 1 -dichloro-2 2-difluoro-ethylene Reference s GB 928 786 Dow appl. 9.2.1960 USA-prior. 3.4.1959 20.7.1959 . Formulations sol. 125 mg 125 ml Trade Name s D Penthrane Abbott wfm I Pentrane Abbott wfm USA Penthrane Abbott wfm GB Penthrane Abbott wfm J Penthrane Abbott Methscopolamine bromide Hyoscine methobromide ATC A03 Use parasympatholytic antispasmodic RN 155-41-9 MF C18H24BrNO4 MW 398.30 EINECS 205-844-5 LD50 26.806 mg kg M Í.V. 619 mg kg M p.o. 42.5 mg kg R i. V. 3400 mg kg R p.o. CN 7 S - la 2ß 4ß 5a 7ß -7- 3-hydroxy-l-oxo-2-phenylpropoxy -9 9-dimethyl-3-oxa-9-azoniatricyclo 3.3.1.02 4 nonane bromide nitrate RN 6106-46-3 MF C18H24N2O7 MW 380.40 EINECS 228-065-2 methylsulfate RN 18067 13-5 MF C18H24NO4 CH3SO4 MW 429.49 EINECS 241-975-4 scopolamine q. V. Br CH-J methyl bromide 1292 M Methyclothiazide Methscopolamine bromide AgNO-j ------ NOJ methscopolomine nitrate Reference s DE 145 996 E. Merck AG appl. 1902 . US 2 753 288 Upjohn 1956 prior. 1952 . Formulation s cps. 2.5 mg syrup 1.25 mg 5 ml tabl. 1.25 mg Trade Name s D Holopon Byk Gulden Oragallin s Hormon- GB Famine Upjohn wfm wfm Chemie -comb. wfm Skopyl Farillon wfm Ichtho-Spasmin Ichthyol - Skopyl Pharmacia as J Ace Ono comb. wfm nitrate wfm Meporamin Taiyo Methyscopolamin Spasmo-Bilicura Mueller USA Pamine Upjohn wfm Upjohn wfm Goppingen -comb. wfm Methyclothiazide ATC CO3AAO8 Use diuretic RN 135-07-9 MF MW 360.24 EINECS 205-172-2 LD50 400 mg kg M i.v. 10 g kg M p.o. 4 g kg R p.o. CN 6-chloro-3- chloromethyl 3 4-dihydro-2-methyl-2 7-l 2 4-benzothiadiazine-7-sulfonamide 1 1-dioxide 5-ch1oro-2 4-di-sulfamoylaniline . 1 . h2n nh2 180 C - HjC I DMF. NaH ------.-------- J urea 7-sulïomoyl-6-chioro-3- 0X0-3 .