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Pharmaceutical Substances Syntheses, Patents, Applications - Part 129

Pharmaceutical Substances Syntheses, Patents, Applications - Part 129. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Methapyrilene M 1281 Methapyrilene ATC R06AC05 Thenylpyramine Use antihistaminic RN 91-80-5 MF C14H19N3S MW 261.39 EINECS 202-099-8 LD 0 20 mg kg M Í.V. 182 mg kg M p.o. CN 7V 7V-dimethyl-W-2-pyridinyl-jV- 2-thienylmethyl -1 2-ethanediamine monohydrochloride RN 135-23-9 MF C14H19N3S HC1 MW 297.85 EINECS 205-184-8 LD5 I 17.5 mg kg M Í.V. 182 mg kg M p.o. 200 mg kg R p.o. fumarate 2 3 RN 33032-12-1 MF CI4H19N3S 3 2C4H4O4 MW 871.00 EINECS 251-351-3 2-pyridyl - methyl ethylenediamine chloride Reference s Weston A.W. J. Am. Chem. Soc. JACSAT 69 980 1947 . US 2 581 868 Monsanto 1952 prior. 1946 . fumarate GB 694 805 Monsanto valid from 1950 USA-prior. 1949 . Formulation s cps. 50 mg 100 mg as hydrochloride Trade Name s D Contac Liquid Vonora - comb. wfm Copyronilum Lilly -comb. wfm Sedanoct Woelm -comb. wfm tiffaforte Tiffapharm as fumarate wfm I Co-Pyronil Lilly wfm USA Alterest Pharmacraft as fumarate -comb. wfm Brexin Savage -comb. wfm Citra Boyle -comb. wfm Co-Pyronil Dista -comb. wfm Ephed-Organidin Wallace wfm Excedrin P.M. Bristol-Myers as fumarate -comb. wfm Hista-Clopane Lilly -comb. wfm Histadyl E.c. Lilly as fumarate -comb. wfm Histadyl Fum. Lilly as fumarate wfm Histadyl Pulvules Lilly wfm Methaqualone ATC N05CM01 Use hypnotic RN 72-44-6 MF C16H14N2O MW 250.30 EINECS 200-780-4 LD5 i 420 mg kg M p.o. 185 mg kg R p.o. CN 2-methyl-3- 2-methylphenyl -4 3H -quinazolinone 1282 M Methazolamide monohydrochloride RN 340-56-7 MF C16H14N2O HC1 MW 286.76 EINECS 206-431-2 LD5 120 mg kg M i.v. 400 mg kg M p.o. 120 mg kg R i.v. 410 mg kg R p.o. H L X 0 - TOOH o-toluidine POCI phosphorus oxychloride N-ocetyl-anlhronilic acid Reference s GB 843 073 Labs. Toraude appl. 22.8.1958 USA-prior. 9.5.1958 . Klosa J. J. Prakt. Chem. JPCEAO 4 20 283 1963 . Formulation s tabl. 200 mg Trade Name s D Normi-Nox Herbrand wfm Optinoxan Robisch wfm Revonal Cascan wfm F Divinoctal I.S.H. -comb. wfm Isonox Ucépha -comb. wfm Mandrax Houdé -comb. wfm Mandrax I.S.H. -comb. wfm GB Revonal Merck wfm