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Pharmaceutical Substances Syntheses, Patents, Applications - Part 212

Pharmaceutical Substances Syntheses, Patents, Applications - Part 212. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Trihexyphenidyl T 2111 Trihexyphenidyl ATC N04AA01 Benzhexol Use antiparkinsonian RN 144-11-6 MF C20H31NO MW 301.47 EINECS 205-614-4 LD50 41 mg kg M i.v. 335 mg kg M p.o. CN ct-cyclohcxyl-a-phenyl-1 -piperidinepropanol hydrochloride RN 52-49-3 MF C20H31NO HC1 MW 337.94 EINECS 200-142-5 LD50 39 mg kg M i.v. 217 mg kg M p.o. 30 mg kg R i.v. 1630 mg kg R p.o. CH20 x -n0 ------------ 3-piperidino- aceto- poraform- piperidine phenone aldehyde propiophenone I cyclohexylmagnesium bromide Reference s US 2 680 115 Winthrop-Stearns 1954 prior. 1949 . US 2 716 121 American Cyanamid 1955 prior. 1946 1949 . alternative synthesis US 2 682 543 Burroughs Wellcome 1954 appl. 1951 . Formulation s amp. 10 mg 5 ml elixir 2 mg 5 ml tabl. 2 mg 5 mg 15 mg as hydrochloride Trade Name s D Artane Lederle GB Broflex Bioglan Pyramistin Yamanouchi Parkopan Neuro Hexal I Artane Wyeth-Lederle Tremin Schering- F Artane Specia J Artane Lederle Shionogi Parkinane retard Wyeth- Arten Lederle-Takeda as Triphedionon Toho Lederle hydrochloride USA Artane Lederle Trilostane ATC H02CA01 Use adrenocortical suppressant RN 13647-35-3 MF C20H27NO3 MW 329.44 EINECS 237-133-0 CN 2a 4a 5a 17ß -4 5-epoxy-17-hydroxy-3-oxoandrostanc-2-carbonitrile 2112 T Trimazosin 70-hydraxy-4-andro- steno 2 3-d isoxazole Reference s US 3 296 255 Sterling Drug 3.1.1967 USA-prior. 23.6.1958 29.6.1960 29.11.1963 . Neumann H.C. et al. J. Med. Chem. JMCMAR 13 948 1970 . intermediates US 3 135 743 Sterling Drug 2.6.1964 appl. 29.6.1960 . Formulation s cps. 60 mg tabl. 60 mg Trade Name s GB Modrenal Wanskerne USA Modrastane Winthrop- J Desopane Mochida Breon wfm TYimazosin ATC C02CA03 Use antihypertensive RN 35795-16-5 MF C20H29N5O6 MW 435.48 EINECS 252-732-7 CN 4- 4-amino-6 7 8-trimethoxy-2-quinazolinyl -l-piperazinecarboxylic acid 2-hydroxy-2-methylpropyl ester monohydrochloride monohydrate RN 53746-46-6 MF C2ÜH29N5O6 HCl H2O MW 489.96 2-amino-3 4 5-trimethoxy-benzoîc acid 1. NcCN 2. POCI 3. NH3 .CH O 3 HjC O H C O nh2 .