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Pharmaceutical Substances Syntheses, Patents, Applications - Part 114

Pharmaceutical Substances Syntheses, Patents, Applications - Part 114. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Khellin K 1131 Trade Name s D Athmakhell Steigerwald wfm Bilicordan Repha wfm Broncaid Rhone-Poulenc Pharma wfm Cardiopax Wider wfm Coronar-Homocent Fides wfm Coropar Redel wfm Farctil Gewo wfm F Hyperidyst 11 Vogel Weber wfm I losimitan Wider wfm Keldrin Thiemann wfm Puraeton E Dolorgiet wfm Solamin Ardeypharm wfm Khelline Promethazine Berthier Labaz wfm Kellina UCB wfm Nefrolitin Geymonat -comb. wfm Vasokellina papaverina Angelini -comb. wfm 1132 L Labetalol Labetalol atc C07AG01 Use antihypertensive a- and ß-receptor blocker RN 36894-69-6 MF C19H24N2O3 MW 328.41 EINECS 253-258-3 LD50 97.5 mg kg M i.v. 660 mg kg M p.o. 50 mg kg R i.v. 2 g kg R p.o. CN 2-hydroxy-5- l-hydroxy-2- l-methyl-3-phenylpropyl amino ethyl benzamide hydrochloride RN 32780-64-6 MF C19H24N2O3 HC1 MW 364.87 EINECS 251-211-1 LD50 47 mg kg M i.v. 1.45 g kg M p.o. 53 mg kg R i.v. 2.114 g kg R p.o. 1.5 g kg dog p.o. dibenzyl-omine Reference s US 4 012 444 Allen Hanburys .15.3.1977 prior. 29.6.1970 . US 4 066 755 Allen Hanburys 3.1.1978 GB-prior. 30.11.1973 . DOS 2 032 642 Allen Hanburys appl. 1.7.1970 GB-prior. 8.7.1969 . DAS 1 643 224 Allen Hanburys appl. 22.9.1967 GB-prior. 23.9.1966 21.4.1967 . US 3 705 233 Allen Hanburys 5.12.1972 GB-prior. 23.9.1966 . Fomulation s amp. 5 mg ml 50 mg 100 mg tabl. 50 mg 100 mg 200 mg 300 mg 400 mg as hydrochloride Lacidipine L 1133 Trade Name s D Trandate Glaxo 1978 wfm Diurolab Leben s -comb. Ipolab Leben s J Trandate Shim Nihon Jitsugyo-Graxo F Trandate Novartis 1980 Lolum Lifepharma USA Normodyne Schering- GB Trandate Evans 1977 Pressalolo Locatelli Plough 1984 1 Abetol CT Alfabetal Mitim Amipres Salus Research Biotens Kemyos -comb. Trandate Glaxo Wellcome Trandiur Glaxo Wellcome -comb. Trandate Glaxo Wellcome 1984 Lacidipine Lacipil GR-43659X GX-1048 SN-305 ATC C02DE C08CA09 Use once-daily calcium antagonist antihypertensive RN 103890-78-4 MF C26H33NO6 MW 455.55 LD50 3150 mg kg M p.o. 880 mg kg R p.o. CN E -4- 2- 3- l l-dimethylethoxy -3-oxo-l-propenyl .