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Pharmaceutical Substances Syntheses, Patents, Applications - Part 113

Pharmaceutical Substances Syntheses, Patents, Applications - Part 113. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Ketamine K 1121 starting material Kühn M. J. Prakt. Chem. JPCPAO 156 II 103 1940 . b AT 198 263 Synfarma appl. 1955 . Formulation s amp. 1 g 5 ml cps. 250 mg Trade Name s D Kebuzon Steiner F Ketazone Beytout wfm I Chetopir Sarm wfm J Bichillos Kotani Kentan-S Sawai Ketazon Kyowa Ketazone Kyowa Hakko Ketobutan Santen Ketobutane Yamagata Ketobutazone Sato Toho Ketophczon Kissei Vintop Maruko Ketamine ATC N01AX03 Use analgesic anesthetic RN 6740-88-1 MF C13H16C1NO MW 237.73 EINECS 229-804-1 LDS0 77 mg kg M i.v. CN -2- 2-chlorophenyl -2- methylamino cyclohexanone monohydrochloride RN 1867-66-9 MF C13H16C1NO HC1 MW 274.19 EINECS 217-484-6 2-chloro- benzoyl -cyclopentone Br2 CCI4. ------ 2-chloro- cyclopentylbenzonitrile magnesium bromide 1 liq. H3C NH2 methylamine Reference s US 3 254 124 Parke Davis 31.5.1966 prior. 31.7.1961 29.6.1962 . BE 634 208 Parke Davis appl. 27.6.1963 USA-prior. 29.6.1962 . Formulation s boiling decaline ----------------- amp. 50 mg 5 ml 100 mg 2 ml 500 mg 10 ml inj. 5 mg ml 10 mg ml 25 mg ml 50 mg ml as hydrochloride Trade Name s D Ketanest Parke Davis as hydrochloride Velonarcon ASTA Medica AWD as hydrochloride F Ketalar Parke Davis as hydrochloride Kétamine Panpharma Panpharma as hydrochloride GB Ketalar Parke Davis I Ketalar Parke Davis J Ketalar Sankyo USA Ketaject Bristol wfm Ketalar Parke Davis wfm Ketalar Parke Davis as hydrochloride wfm Ketaset Bristol-Myers Squibb as hydrochloride wfm 1122 K Ketanserin Ketanserin ATC C02KD01 Use antihypertensive RN 74050-98-9 MF C22H22FN3O3 MW 395.43 EINECS 277-680-2 CN 3- 2- 4- 4-fluorobenzoyl -l-piperidinyl ethyl -2 4 U 3 -quinazolinedione 1 -benzyl-4-cyano-piperidine 4-fluorophenyh magnesium bromide 0 Ji No CO- 0 4- 4-fluarobenzoyl -piperidine III OyO CHj H O CH-j 0 ------------ 2-amino-ethanol 3- 2-hydraxyethyl -2 4 1 H 3H -quinozo-linedione IV 1. SOCI2 2. Ill IV ----------------- 1. thianyl chloride Reference s EP 13 612 Janssen appl. 7.1.1980 USA-prior. 8.1.1979 12.10.1979 . US 4 335 127 Janssen