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Pharmaceutical Substances Syntheses, Patents, Applications - Part 112

Pharmaceutical Substances Syntheses, Patents, Applications - Part 112. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Isoxicam I 1111 CH3 Z - -formyl-crotonic acid cf. retina synthesis COOH Reference s Garbers C.F. et al. J. Chem. Soc. C JSOOAX 1968 1982. Z -ß-formylcrotonic acid Conradie W.J. et al. J. Chem. Soc. C JSOOAX 1964 594. combination with taurine US 4 545 977 Searle 8.10.1985 appl. 11.1.1985 . medical use DE2061 507 Hoffmann-La Roche appl. 8.7.1971 prior. 14.12.1970 . US 3 746 730 Hoffmann-La Roche 17.7.1973 appl. 17.12.1970 GB-prior. 13.12.1969 . Formulation s cps. 2.5 mg 5 mg 10 mg 20 mg gel 0.05 Trade Namefs D ISOTREX Stiefel Roaccutane Roche 1986 Roaccutane Roche Roaccutan Roche 1985 GB Isotrex Stiefel I Roaccutane Roche F Isotrex Stiefel Isotrexin Stiefel USA Accutane Roche 1982 Isoxicam atc.- M Use anti-inflammatory RN 34552-84-6 MF C14H lN O5S MW 335.34 EINECS 252-084-5 LD5 5 g kg R p.o. CN 4-hydroxy-2-methyl-7V- 5-methyl-3-isoxazolyl -2H-1 2-benzothiazine-3-carboxamide 1 1 -dioxide OH 0 3- ethoxycarbonyl- 4- hydroxy-2-methyl-2H-1 2-benzothiazine 1 1 -dioxide cf. piroxicam synthesis ch3 3-amino-5-methyl-isoxozole Reference s DOS 2 208 351 Warner-Lambert appl. 22.2.1972 USA-prior. 1.3.1971 . Lombardino J.G. Wiseman E.H. J. Med. Chem. JMCMAR 14 973 1971 . Zinnes H. et al. J. Med. Chem. JMCMAR 25 12 1982 . Formulation s cps. 100 mg 1112 I Isoxsuprine Trade Name s D Pacyl Adenylchemie wfm F Vectren Substantia wfm J Floxicam Menarini wfm Maxicam Parke Davis wfm Isoxsuprine ATC C04AA01 Use vasodilator RN 395-28-8 MF ClfiH23NO3 MW 301.39 EINECS 206-898-2 LD50 48 mg kg M i.v. 200 mg kg M p.o. CN 4-hydroxy-a- 1 - 1 -methyl-2-phenoxyethyl amino ethyl benzenemethanol hydrochloride RN 579-56-6 MF C aH23NO3 HC1 MW 337.85 EINECS 209-443-6 LD50 61 mg kg M i.v. 1.1 g kg M p.o. 1.75 g kg R p.o. 57 mg kg dog i.v. 1.2 g kg dog p.o. 4-hydroxy-norephedrine ch3 1-phenoxy-2-bromopropane 4 -benzyloxypropiophenone CHj phencxypropane 1 Isoxsuprine Reference s US 3 056 836 Philips 2.10.1962 NL-prior. 28.5.1955 . GB 832 286 Philips appl. 11.10.1957 NL-prior. 15.10.1956 . GB 832 287 Philips