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Pharmaceutical Substances Syntheses, Patents, Applications - Part 96

Pharmaceutical Substances Syntheses, Patents, Applications - Part 96. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Gallium nitrate G 951 Gallium nitrate ATC V03AG Use hypocalcemic agent against cancer- related hypercalcemia RN 13494-90-1 MF GaN3O9 MW 255.74 EINECS 236-815-5 LDS0 55 mg kg M i. v. 4360 mg kg M p.o. 600 mg kg M s.c. 46 mg kg R i.v. CN gallium nitrate A Go HNOj ------------ Ga NOj j Gallium nitrate Reference s Dupre A. C. R. Hebd. Seances Acad. Sei. COREAF 86 721 1878 medical use as hypocalcemic agent EP 109 564 Sloan Kettering Inst. appl. 21.10.1983 USA-prior. 22.10.1982 . US4 529 593 Sloan Kettering Inst. 16.7.1985 prior. 20.6.1984 22.10.1982 . medical use as antitumor effect enhancer JP 1 104 016 Taishitsu Kenkyukai appl. 31.7.1987 . Formulation s vial 500 mg Trade Name s USA Ganite SoloPak Gallopamil ATC C01DA C08DA02 Use coronary vasodilator verapamil analog RN 16662-47-8 MF C28H40N2O MW 484.64 CN a- 3- 2- 3 4-dimethoxyphenyl ethyl methylamino propyl -3 4 5-trimethoxy-a- 1 - methylethyl benzeneacetonitrile hydrochloride RN 16662-46-7 MF HC1 MW 521.10 N cn .o- .0 CH-J y o-ch H3C C1 CH3 CH3 o. .0 CH-J CH- Ck ch3 3 4 5-trimethoxy- 2-chloro- propane 2- 3 4 5-trimethoxyphenyl - 3- methylbutyronitrile 1 phenylacetonitrife N- 2- 3 4-dimeth-oxyphenyl ethyl -methylomine h3c o. H3c-o- CH-j ch3 1 -bromo-3-chloropropane 952 G Gamolenic acid NaNHj I Il ----------------- sodium amide Reference s DE 1 154 810 Knoll appl. 28.4.1961 . DE 1 158 083 Knoll appl. 19.12.1962 . DE 2 059 985 Knoll prior. 5.12.1970 . Formulation s f. c. tabl. 25 mg 50 mg s. r. tabl. 100 mg as hydrochloride Trade Name s D Gallopamil ct- Arzneimittel Procorum retard Knoll I 1983 Algocor Ravizza Procorum Knoll Gamolenic acid RN 506-26-3 MF C18H30O2 MW 278.44 CN Z Z Z -6 9 12-octadecatrienoic acid potassium salt RN 106868-38-6 MF C18H29KO2 MW 316.53 sodium salt RN 86761-55-9 MF C18H29NaO2 MW 300.42 ATC Dl 1AX02 Use treatment of eczema a From fermentation of Mortierella. b From fermentation of mucor. c Extration and isolation from natural sources seeds of black currant evening primrose borage . Gamolenic .