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Pharmaceutical Substances Syntheses, Patents, Applications - Part 111

Pharmaceutical Substances Syntheses, Patents, Applications - Part 111. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Isoetarine I 1101 Cl A Br2. CH-jOH Cl a H CH OH VN 3 Cl JÔ Cl bromine cr A F imidazole ci- y HjA r o Ao Br Ö 2 4 -dîchloro- 2-bromo- 1 - 2 4-dichloro- acetophenone 2 4 -dichloro-acetophenone phenacyljimidozole 1 Cl NqBH4 ch3oh sodium borohydride 1 - 2 4-dichloro-phenyl -2- 1 H-imidazol-1 -yl -ethonol 2 6-dichloro-benzyl chloride Reference s DOS 1 940 388 Janssen appl. 8.8.1969 USA-prior. 19.8.1968 . US 3 717 655 Janssen 20.2.1973 prior. 19.8.1968 23.7.1969 . US 3 839 574 Janssen 1.10.1974 prior. 19.8.1968 23.7.1969 19.7.1972 . Godefroi E.F. et al. J. Med. Chem. JMCMAR 12 784 1969 . Formulation s cream 10 mg g 1 pessaries 100 mg . 300 mg 600 mg as nitrate spray 10 mg ml Trade Name s D Bi-Vaspit Asche -comb. F Fazol Bellon Rhone- Travocort Schering -comb. Travocort Schering -comb. Poulenc Rorer 1979 Travogen Schering Travogen Schering 1979 GB Travogyn Schering J Adestan Schering I Isogyn Crosara Isoetarine ATC R03AC07 RO3CCO6 Etyprenalinum Isoetharine Use bronchodilator sympathomimetic RN 530-08-5 MF C13H21NO3 MW 239.32 EINECS 208-472-1 CN 4- l-hydroxy-2- l -methylethyl amino butyl -1 2-benzenediol hydrochloride RN 50-96-4 MF C13H21NO3 HC1 MW 275.78 LD50 57 mg kg M i.v. 3 4 -dibenzyloxy-butyrophenone Br2 isopropylamine 1102 I Isoflupredone acetate i H2 Pd-C ------- Reference s DRP 638 650 I. G. Farben 1934 . Formulation s amp. 1 mg 2.4 mg 5 mg 5.1 mg sol. for inhalation 0.125 0.61 1 as hydrochloride Trade Name s D Asthmalitan Kettelhack- GB Bronchilator Sterling USA Bronkometer Sanofi - Riker wfm Res. wfm comb. Numotac Riker wfm Bronkosol Sanofi -comb. Isoflupredone acetate ATC H02AB Use glucocorticoid RN 338-98-7 MF C23H29FO6 MW 420.48 EINECS 206-423-9 CN llß -21- acetyloxy -9-fluoro-l l 17-dihydroxypregna-l 4-diene-3 20-dione isoflupredone RN 338-95-4 MF C21H27FO MW 378.44 EINECS 206-422-3 fludrocortisone 21-acetóte cf. fludrocortisone synthesis Reference s DE 1 096 900 American Cyanamid appl. 1959 USA-prior. 1958 . microbiological dehydrogenation with .