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Pharmaceutical Substances Syntheses, Patents, Applications - Part 95

Pharmaceutical Substances Syntheses, Patents, Applications - Part 95. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Framycetin F 941 i ci NC0 CH 0 P nAj H H 0 x CHj NoN02 HCOOH sodium nitrite formic acid ch3 Fotemustine 2-chloroethyl N- 2-chloroethyl -N - socyonote 1 - diethoxyphosphoryl - ethyljureo Reference s EP 117 959 ADIR appl. 16.11.1983 F-prior. 17.11.1982 . US4 567 169 ADIR 28.1.1986 F-prior. 17.11.1982 . synthesis o a-aminoethylphosphonic acid diethyl ester Berlin K.D. et al. J. Org. Chem. JOCEAH 33 3090 1968 . Kowalik J. Mastalerz P. Synthesis SYNTBF 1981 57. Oleksyszyn J. Tyka R. Tetrahedron Lett. TELEAY 22 2823 1977 . Formulations amp. 208 mg Trade Narne s F Muphoran Servier 1990 Framycetin Neomycin B ATC R01AX08 Use antibiotic RN 119-04-0 MF C23H46N6O13 MW 614.65 EINECS. 204-292-2 CN ö-2 6-diamino-2 6-dideoxy-a-D-glucopyranosyl l- 4 -0- 0-2 6-diamino-2 6-dideoxy-ß-L-idopyranosyl- 1 - 3 -ß-D-ribofuranosyl- 1 - 5 -2-deoxy-D-streptamine sulfate 1 3 RN 4146-30-9 MF C23H46N6O13 3H2SO4 MW 908.88 EINECS 223-969-3 From fermentation solutions of Streptomyces fradiae. 942 F Fumagillin Reference s US 2 799 620 Rutgers Res. Found. 16.7.1957 prior. 29.6.1956 . purification US 2 848 365 Upjohn 1958 appl. 1950 . US 3 005 815 Merck Co. 24.10.1961 prior. 1955 1957 . US 3 022 228 S. B. Penick 20.2.1962 appl. 19.1.1960 . US 3 108 996 Upjohn 29.10.1963 appl. 30.7.1962 . Formulation s cream 0.5 drops 1.25 eye drops 0.5 ointment 20 mg g powder 20 mg g spray 500 mg 203.5 g tabl. 250 mg as sulfate Trade Name s D Leukase SmithKline I Cheliboldo Terapeutico - NeoDecadron Merck as Beecham Sofra Tüll Albert-Roussel Hoechst comb. Crisolax Lifepharma -comb. sulfate Neomycin Sulfate Roxane F Néomycine Diamant Diamant -comb. and more than 50 combination preparations Sofra-tulle Roussel J Dexmy Takeda Fradio Nippon Kayaku USA Coly-Mycin Parke Davis - Neomycin Sulfate Teva Neosporin Glaxo Wellcome as sulfate Neosporin Warner- GB Sofradex Florizel -comb. Soframycin Hoechst -comb. Sofra-Tulle Hoechst as sulfate comb. Cortisporin Monarch as sulfate Lazersporin-C Pedinol as sulfate Lambert Fumagillin .