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Pharmaceutical Substances Syntheses, Patents, Applications - Part 109

Pharmaceutical Substances Syntheses, Patents, Applications - Part 109. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | lodamide I 1081 H2 Roney-Ni ------------- Referenced FR5 997 M Dagra appl. 23.11.1966 prior. 25.11.1965 26.5.1966 . Formulationd tabl. 500 mg 750 mg Trade Named D Cholebrine F Cholebrine Schering USA Cholebrine Mallinckrodt Mundipharma wfm wfm wfm 1 Colebrin Schering wfm lodamide Jodamid ATC VO8AAO3 Use X-ray contrast medium RN 440-58-4 MF C12HIII3N2O4 MW 627.94 EINECS 207-125-1 LD50 7 g kg M p.o. 7 g kg R p.o. CN 3- acetylamino -5- acetylamino methyl -2 4 6-triiodobenzoic acid meglumine salt RN 18656-21-8 MF C12HnI3N2O4 C7H17NOS MW 823.16 EINECS 242-480-6 H ci2hc n oh 0 H2S04 HCI CH3COOH 3- aminamethyl- 4- chlorobenzoic acid 1 COOH 4-chloro- 2 2-dichloro-N- benzoic hydroxymethyl- acid acetamide 1082 I lodoxamic acid IV 11 H h3cvn 0 COOH 1 0 u N CH H J lodomide Reference s US 3 360 436 Eprova appl. 12.11.1963 CH-prior. 23.11.1962 9.8.1963 . GB 1 002 344 Eprova appl. 3.10.1963 CH-prior. 23.11.1962 9.8.1963 . DE 1 273 747 Eprova appl. 24.9.1963 CH-prior. 23.11.1962 . Formulation s amp. 300 mg 380 mg 420 mg as meglumine salt Trade Name s D Uromiro Heyden wfm Opacist E.R. Bracco J Conraxin Takeda I Isteropac E.R. Bracco Uromiro Bracco lodoxamic acid ATC V08AC01 Use X-ray contrast medium cholangiography RN 31127-82-9 MF C26H26I6N2O10 MW 1287.92 EINECS 250-478-1 LD5 i 13.65 g kg M i.v. CN 3 3 - l 16-dioxo-4 7 10 13-tetraoxahexadecane-l 16-diyl diimino bis 2 4 6-triiodobenzoic acid meglumine salt 1 2 RN 51764-33-1 MF C26H26I6N2O10 2C7H17NO5 MW 1678.35 EINECS 257-398-6 NC CH2 hO- o - O -.oh acrylonitrile triethylene glycol 4 7 10 13-tetrooxahexadecane-dinitrile I 1. h2so4 c2h5oh 2. NaOH 3. SOCI2 0 4 7 10 13-tetrooxahexadecanedioyl chloride 11 COOH 3-amino-2 4 6-triiodobenzoic dimethyl-ocetomide lodoxamic ocid Reference s DE 1 937 211 Bracco appl. 22.7.1969 . Formulation s amp. 3.66 g 5.49 g 8.06 g 9.91 g 12.09 g as meglumine salt lofendylate I 1083 Trade Name s D Endomirabil Byk Gulden wfm I Endobil Bracco J Cholegrafin Takeda lofendylate lophendylate ATC V08AD04 Use X-ray