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Pharmaceutical Substances Syntheses, Patents, Applications - Part 106

Pharmaceutical Substances Syntheses, Patents, Applications - Part 106. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Imidapril I 1051 Trade Name s D Ilomedin Schering 1992 I F Ilomedine Schering Endoprost Schering Ilomedin Schering Imidapril TA-6366 ATC C09A Use antihypertensive ACE inhibitor RN 89371-37-9 MF C20H27N3O6 MW 405.45 CN 45- 3 R 42 -3- 2- I - ethoxycarbonyl -3-phenylpropyl amino -1 -oxopropyl -1 -methyl-2-oxo-4-imidazolidinecarboxylic acid monohydrochloride RN 89396-94-1 MF C2 H27N3O6 HC1 MW 441.91 VZX N COOH OCC THF 0 DC ------------ 2S -2- lS -1-ethoxy- carbonyi-3-phenylpropyl-ominojpropianic acid succinimido ester 1 2S -2- 1S -1-ethoxy-carbonyl-3-phenyl-propylamino propionic acid benzyl 4S -1-methyl-2-oxo-imidazolidine-4-carboxylate koc ch3 3. THF. -40 C H3C benzyl 4S -1-methyl-3- 2S - 2- 1S 1-ethoxycarbonyl-3-pheryl- prapylomino propionyl -2-oxo- imidozolidine-4-corboxylate 11 U H2 Pd-C ethanol 1052 I Imipenem tert-butyl 4S -1-methyl-2-oxoirni-dozolidine 4-corboxylote 2R -2- p-toluene sulfonyloxy pro-piony chloride koc ch3 3 THF -50 C -------------- . HjC tert-butyl 4S -1- methyl-3- 2R -2- p-toluenesulfonyloxy propionyl -2-oxoimido- zolidine-4-corboxylate Ill N C2H5 3 DMSO ---------- HCI dioxane Imidopril h3c ethyl 2S -2-aminO-4-phenyl-butyrate Reference s a EP 95 163 Tanabe Seiyaku appl. 20.5.1983 J-prior. 24.5.1982 . b EP 373 881 Tanabe Seiyaku appl. 12.12.1989 J-prior. 16.12.1988 . formulation with increased stability JP 06 100 447 Tanabe Seiyaku appl. 24.9.1992 J-prior. 24.9.1992 . composition for treatment of kidney diseases JP 272 849 Tanabe Seiyaku appl. 10.12.1987 J-prior. 12.12.1986 . composition for treatment of heart failure EP 274 230 Tanabe Seiyaku appl. 8.12.1987 J-prior. 9.12.1986 . I b r mulatto n s tabl. 2.5 mg 5 mg 10 mg as hydrochloride Trade Name s J Novaroc Nihon Schering Tanatril Tanabe Seiyaku Imipenem Imipemide ATC J01DH51 Use ß-lactam antibiotic RN 64221-86-9 MF C12H17N3O4S MW 299.35 EINECS 264-734-5 LD5 i 1660 mg kg M i.v. 5 g kg M p.o. 1972 mg kg R i.v. 5 g kg R p.o. CN 57 - 5a 6a J -6- l-hydroxyethyl -3- 2- iminoniethyl amino ethyl thio