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Pharmaceutical Substances Syntheses, Patents, Applications - Part 21

Pharmaceutical Substances Syntheses, Patents, Applications - Part 21. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Bentiamine B 201 2 3 4-trihydroxy- DL-serine N- DL-seryl -2 3 4- benzaldehyde hydrazide trihydroxybenzaldehyde hydrazone I Reference s DE 1 165 607 Roche appl. 8.5.1962 CH-prior. 16.6.1961 . US 3 178 476 Roche 13.4.1965 CH-prior. 16.6.1961 . L-form US 3 557 292 Roche 19.1.1971 appl. 16.8.1968 . DE 1 941 284 Roche appl. 13.8.1969 CH-prior. 16.8.1968 . DAS 1 966 821 Roche appl. 13.8.1969 CH-prior. 16.8.1968 . Fortnulation s cps. 12.5 mg 14.25 mg 25 mg 28.5 mg 50 mg dispersible tabl. 12.5 mg 25 mg s. r. cps. 28.5 mg tabl. 28.5 mg 57 mg Trade Name s D Madopar Roche -comb. I Madopar Roche -comb. Madopair Roche -comb. with levodopa wfm with levodopa F Modopar Roche -comb. Madopar Roche -comb. Neodopasol Daiichi - with levodopa with levodopa wfm comb. with levodopa GB Madopar Roche -comb. J EC-doparl Kyowa Hakko - with levodopa comb. with levodopa Bentiamine ATC AH Dibenthiamine Dibenzoylthiamine Use vitamin B.-derivative neurotropic analgesic RN 299-88-7 MF C26H26N4O4S MW 490.58 EINECS 206-084-7 LD5 i 7480 mg kg M p.o. CN benzenecarbothioic acid 5- 2- 4-amino-2-methyl-5-pyrimidinyl methyl formylamino -l- 2- benzoyloxy ethyl -1-propenyl ester NaOH ------ CHO SH Y 5 HO thiamine q. V. ch3 nh2 N- 4 - omina- 2-methylpyrtmidin-5-yfmethyl -N- 4-hydroxy-1 -methyl-2-mercaptobut-1 -enyl -formamide 1 202 B Bentiromide benzoyl chloride Bentiamine Reference s US 2 752 348 Takeda 1956 J-prior. 1952 . Matsukawa T. Kawasaki H. Yakugaku Zasshi YKKZAJ 23 705 1953 . Trade Name s D only combination preparations wfm Bentiromide ATC V04CK03 Use pancreas function diagnostic RN 37106-97-1 MF C23H20N2O5 MW 404.42 EINECS 253-349-8 LD50 1020 mg kg M i.v. 6 g kg M p.o. 485 mg kg R i.V. 6 g kg R p.o. . CN S -4- 2- benzoylamino -3- 4-hydroxyphenyl -l-oxopropyl amino benzoic acid L-tyros ne benzoyl N-benzoyl-L-tyrosine l chloride I.O JM-CHj THF 2. CICOOC2H5 COOH 3. JT J . TosOH 1. 4-methylmorpholine 2. ethyl chloroformate 3. 4-ominobenzoic acid Reference s Benneville P.L. de et al. J. Med. Chem. .