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Pharmaceutical Substances Syntheses, Patents, Applications - Part 18

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Pharmaceutical Substances Syntheses, Patents, Applications - Part 18. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Aztreonam A 171 1. CISOjH 2-picoline CH2CI2 2. V CH2CI2 ------------------------------ N1-sulfo-N2-benzyloxycorbonyl-O-methylsulfonyl-L-threoninamide tetrabutylammonium salt XII VIII K2CO3 C2H CI2 H2O M2 Pd-C C2H50H N-hydroxybenzotriazole DCC xn----------- -------------V ---------------- ----------- VII ---------------------------------- IX anisole. CFjCOOH -------- I------------ Aztreonam Reference s US 4 386 034 Squibb 31.5.1983 prior. 10.2.1982 . US4529 698 Squibb 16.7.1985 prior. 5.11.1984 . US 4 625 022 Squibb prior. 25.11.1986 2.2.1981 . DOS 3 104 145 Squibb appl. 6.2.1981 USA-prior. 29.8.1980 . GB 2 071 650 Squibb appl. 6.2.1981 USA-prior. 7.2.1980 29.9.1980 . Formulations amp. 2 g inj. powder 500 mg 1 g 2 g lyo. for inf. 2 g vial 1 g 3 nil Trade Name s D Azactam Bristol-Myers GB Azactam Bristol-Myers J Azactam Squibb 1987 Squibb 1985 Squibb 1986 USA Azactam Bristol-Myers F Azactam Sanofi Winthrop I Azactam Squibb 1984 Squibb 1987 172 B Bacampicillin Bacampicillin atc joicaoö Use antibiotic broad spectrum penicillin RN 50972-17-3 MF C21H27N3O7S MW 465.53 CN 2S- 2a 5a 6ß S -6- aminophenylacetyl amino -3 3-dimethyl-7-oxo-4-thia-1 -azabicyclo 3.2.0 heptane-2-carboxylic acid l- ethoxycarbonyl oxy ethyl ester monohydrochloride RN 37661-08-8 MF C21H27N3O7S HCl MW 501.99 EINECS 253-580-4 LD50 184 mg kg M i.v. 8529 mg kg M p.o. 176 mg kg R i.v. 10 g kg R p.o. CH30 dmf azidocillin sodium salt 1-chloroethyl q. V. ethyl carbonote 6- D-a-azidaphenylacetamido -penicillanic acid 1-ethoxycarbonyloxyethyl ester 1 Reference s DAS 2 144457 Astra appl. 4.9.1971 S-prior. 17.9.1970 20.11.1970 . US 3 873 521 Astra 25.3.1975 S-prior. 17.9.1970 20.11.1970 . US 3 939 270 Astra 17.2.1976 S-prior. 17.9.1970 20.11.1970 . Formulation s f. c. tabl. 400 g 800 mg susp. 125 mg as hydrochloride Trade Name s D Ambacamp Pharmacia Penglobe Lematte et Bacacil Pfizer Upjohn 1981 Boinot Penglobe Bracco Penglobe Astra 1977 GB Ambaxin Upjohn 1980 J Bacacil Pfizer Taito F Bacampicine Pharmacia I .

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