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Pharmaceutical Substances Syntheses, Patents, Applications - Part 16

Pharmaceutical Substances Syntheses, Patents, Applications - Part 16. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Atropine A 151 ocryloyl pentane- tetrahydfopapaverine I chloride 1 5-diol I methyl benzene- sulfonate Reference s DOS 2 655 883 Wellcome appl. 9.12.1976 GB-prior. 10.12.1975 29.10.1976 . US 4 179 507 Wellcome 18.12.1979 GB-prior. 10.12.1975 29.10.1976 . Stenkale J.B. et al. Eur. J. Med. Chem. EJMCA5 16 515 1981 . Formulation s amp. 25 mg 2.5 ml 50 mg 5 ml Trade Name s D Tracrium Glaxo Wellcome 1987 F Tracrium Glaxo Wellcome GB Tracrium Wellcome 1982 I Tracrium Wellcome USA Tracrium Glaxo Wellcome 1983 Atropine DL-Hyoscyamine ATC A03BA01 S01FA01 Use anticholinergic mydriatic antispasmodic RN 51-55-8 MF C1 Hi3NO3 MW 289.38 EINECS 200-104-8 LD50 30 mg kg M i.v. 75 mg kg M p.o. 73 mg kg R Í.V. 500 mg kg R p.o. CN e ỉófo- -a- hydroxymethyl benzeneacetic acid 8-methyl-8-azabicyclo 3.2.1 oct-3-yl ester 152 A Atropine methonitrate borate 1 1 RN 51460-78-7 MF CI7H23NO3 H3BO3 MW 351.21 sulfate 2 1 RN 55-48-1 MF C17H23NO3 1 2H2SO4 MW 676.83 EINECS 200-235-0 LD5 31 mg kg M i.v. 468 mg kg M p.o. 37 mg kg R i.v. 600 mg kg R p.o. 60 mg kg dog i.v. By extraction of Solanacean drugs especially Atropa belladonna Hyoscyamus niger or other species. On careful extraction L-hyoscyamine is obtained first which can be racemized to atropine by addition of alkali in ethanolic solution. Reference s Ullmanns Encykl. Tech. Chem. 3. AufL Vol. 3 201 f. Ullmanns Encykl. Tech. Chem. 4. Aufl. Vol. 7 151. Formulation s amp. for inj. 100 mg eye drops 10 mg inj. sol. 0.25 mg 0.5 mg 1 mg 2 mg tabl. 0.5 mg Trade Name s Angiocardyl Rhenomed Chibro-Atropine Merck generics Farmigea Scfm Atropin in der Ophtiole Sharp Dohme-Chibret and combination Mann generics and numerous preparations Atropinol Augentropfen combination preparations J generics Winzer GB Lomotil Searle -comb. USA Arco-Lase Plus Arco Atropin POS Ursapharm I Atropina Aolfato Scfm Atrohist Plus Medeva Borotropin Augentropfen Atropina Lux Allergan as Bellatal Richwood Winzer sulfate Donnatal Robins Cansat Sanofi Winthrop Atropi S Formulario Naz.