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Pharmaceutical Substances Syntheses, Patents, Applications - Part 71

Pharmaceutical Substances Syntheses, Patents, Applications - Part 71. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | F Dolasetron mesilate D 701 1. NqBH4 CHjOH VI 1. tBu-OK toluene 100 C VII synthesis of intermediate VIII COOH JI JI f5c ocf5 ch2ci2 vm indole-3- trifluoroacetic carboxylic acid anhydride alternative preparation via 0-methoxycarbonylglutaraldehyde n CH3 1. LiH DMF 2. NaOH MeOH r- 0 r w o ch3 m-chloroperbenzoic acid X dimethyl methyl malonate 3-cyclopentene- 1-carboxylate IX HIO4 h3C U 0 CH3 ------------------- OHC . 0 ohc o ch3 diostereomeric mixture of 1 -methoxycarbonyl-3-cyclopentene oxide trans cis 3 1 X 0-methoxycarbonyl-glutoraldehyde XI D 702 Domiodol 1. D3 MeOH H2O -5 to 0 C 2. H3C-S-CH3 K --------------------------------XI 1. ozone 2. dimethyl sulfide Dolosetron mesilate Referenced s EP 339 669 Merrell Dow Pharm. Inc. appl. 28.4.1989 USA-prior. 29.4.1988 . EP 266 730 Merrell Dow Pharm. Inc. appl. 2.11.1987 USA-prior. 3.11.1986 . Formulation s amp. 12.5 mg 0.625 ml 100 mg 5 ml f. c. tabl. 50 mg 200 mg Trade Named s D Anemet Hoechst Marion USA Anzemet Hoechst Marion Roussel 1997 Roussel 1997 Domiodol ATC R05CB08 Use mucolytic agent RN 61869-07-6 MF C5H9IO3 MW 244.03 LD5o 79-89 mg kg M i.v. 140-145 mg kg M p.o. CN 2- iodomethyl -1 3-dioxolane-4-methanol glycerol 1 -benzyl ether h3c oy HjC .0 bromoacetaldehyde diethyl acetal Pd-C ----- Nal ---- --- sodium iodide Referenceds DOS 2 610 704 Maggioni appl. 13.3.1976 I-prior. 2.4.1975 . Formulation s sachet 60 mg sugar coated tabl. 60 mg syrup 0.6 Trade Name s I Mucolitico Maggioni- Winthrop Domiphen bromide Phenododecinium bromide ATC A01AB06 Use disinfectant RN 538-71-6 MF C22H40BrNO MW 414.47 EINECS 208-702-0 LDS0 31 mg kg M i.v. 18 mg kg R i.v. CN N V-dimethyl- V- 2-phenoxyethyl -1 -dodecanaminium bromide Domperidone D 703 2-phenoxyethyl bromide 1 .CH HN- 3 ch3 dimethylamine dimethyl- 2-phen- oxyethyl amine II 3 dodecylamine dodecyl 2-phenoxyethyl omine HI HCOOH in HCHO------- 3 ch3 Br CH3 methyl bromide Domiphen bromide Reference i US 2 581 336 Ciba 1952 CH-prior. 1944 . Formulations tabl. 0.5 mg Trade Name s .