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Pharmaceutical Substances Syntheses, Patents, Applications - Part 65

Pharmaceutical Substances Syntheses, Patents, Applications - Part 65. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Difl ucortolone valerate D 641 .dio UCh 3 N N -dibromo-5 5- dimethylhydantoin Reference s DE 1 211 194 Schering 27.7.1963 continuation of DE 1 169 444. DEI 169 444 Schering 22.2.1961 . Kieslich K. et al. Arzneim.-Forsch. ARZNAD 26 1462 1976 . alternative syntheses described Formulations cream 0.1 ointment 0.1 Trade Name s D Neribas Schering Nerisona Schering Nerisona C Schering -comb. Travocort Schering -comb. F Nerisone Schering as valerate Nerisone C Schering as valerate -comb. GB Nerisone Schering I Cortical Caber Cortifluoral Schering -comb. Dermaflogil Nuovo Cons. Sanit. Naz. -comb. Dermeval Firma Dermobios Biotekfarma -comb. Dervin Boniscontro Gazzone Dicortal Medici Flu-Cortanest Piam Impetex Roche -comb. Nerisona Schering Nerisona C Schering -comb. Temetex Roche several combination preparations Afusona Toyama Arusona Hotta Dertron Sankyo Lizatlone Kaken Lorizon Shinshin Neridalon Taiyo Nerisona Nippon Schering Sawatolone Sawai Texmeten Roche Youtolon Tatsumi 642 D Diflunisal Diflunisal ATC N02BA11 Use anti-inflammatory analgesic antipyretic RN 22494-42-4 MF C13H8F2O3 MW 250.20 EINECS 245-034-9 LD5o 439 mg kg M p.o. 392 mg kg R p.o. CN 2 4 -difluoro-4-hydroxy l l -biphenyl -3-carboxylic acid ON _ --------------- isoamyi nitrite 4- 2 4 dif1uoro- phenyl anisole 2.4-difluoro- anisole aniline 4- 2 4-difluoro-phenyl phenol 1 Reference s Hannah J. et al. J. Med. Chem. JMCMAR 21 1093 1978 . DE 1 618 663 Merck Co. appl. 3.3.1967 USA-prior. 8.9.1966 . DAS 2 532 559 Merck Co. appl. 21.7.1975 USA-prior. 22.7.1974 16.4.1975 1.5.1975 . US 3 674 870 Merck Co. 4.7.1972 appl. 9.6.1970 USA-prior. 23.12.1964 8.9.1966 19.1.1968 . US 3 681 445 Merck Co. 1.8.1972 appl. 19.1.1968 USA-prior. 23.12.1964 8.9.1966 . US 3 714 226 Merck Co. 30.1.1973 appl. 9.6.1970 prior. 23.12.1964 8.9.1966 19.1.1968 . alternative syntheses US 3 992 459 Merck Co. 16.11.1976 appl. 1.5.1975 . US 4 131 618 Merck Co. 26.12.1978 appl. 29.12.1977 . US 4 225 730 Merck Co. 30.9.1980 appl. 11.5.1978 prior. .