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Design, in silico studies, synthesis, and in vitro anticancer assessment of new naphthylidene isoxazolidinedione derivatives

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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively. | Received 21 April 2023 Revised 27 September 2023 Accepted 7 October 2023 DOI 10.1002 vjch.202300148 RESEARCH ARTICLE Design in silico studies synthesis and in vitro anticancer assessment of new naphthylidene isoxazolidinedione derivatives Neha Upadhyay1 Kalpana Tilekar1 Aditi Oak1 Vadim S. Pokrovsky2 3 Ramaa Subramanian Chelakara1 1 Department of Pharmaceutical Chemistry Bharati Vidyapeeth s College of Pharmacy CBD Abstract Belapur Navi Mumbai India Cancer is the most destructive and fatal disease representing an urgent med- 2 Laboratory of Biochemical Fundamentals of ical challenge to the world. The discovery of a new anticancer candidate may Pharmacology and Cancer Models N. N. Blokhin help reduce or eliminate this alarming disease to a greater extent. On similar Cancer Research Center Moscow Russia lines in silico research was carried out on novel naphthylidene isoxazolidinedione 3 Department of Biochemistry People s derivatives that were logically conceived synthesized purified and structurally Friendship University Moscow Russia characterized. In vitro biological evaluation revealed the most active compound Correspondence 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM Ramaa Subramanian Chelakara Department of on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione Pharmaceutical Chemistry Bharati Vidyapeeth s derivative was evident by cell cycle and apoptosis assays which showed arrest of College of Pharmacy CBD Belapur Navi Mumbai 400614 India. the G2 M phase 65.6 of the K562 cells and induction of apoptosis with 21.47 Email sinharamaa@yahoo.in apoptotic cells as compared to 0.2 of untreated cells respectively. Funding information KEYWORDS ASEAN-India S amp T Development Fund AISTDF antiproliferative apoptosis bio-isostere cell cycle isoxazolidinedione Grant Award Number IMRC AISTDF CRD 2018 000001 1 INTRODUCTION incorporated a common pharmacophoric feature which is a heterocyclic ring 2 4-thiazolidinedione

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