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Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
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The human EGFR2 (HER2) signaling pathway is one of the most actively studied targets in cancer transformation research. Triplex-forming oligonucleotides (TFOs) activate DNA damage and induce apoptosis. We aim to encapsulate TFO-HER2 with nano-particle ZW-128 to suppress breast cell growth in vitro and in vivo. |