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Neoadjuvant chemotherapy with modified FOLFOXIRI for locally advanced rectal cancer to transform efectively EMVI and MRF from positive to negative: Results of a long-term single center phase 2 clinical trial

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Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherapy with mFOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan) in LARC. |

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