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Development and validation of a method for quantification of two tobacco-specific nitrosamines in indoor air

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A sensitive and accurate method for the quantification of 1 -Demethyl-1 -nitrosonicotine (NNN) and 4-(methylnitrosamino)-1-(3-Pyridyl)-1-butanone (NNK) in indoor air was developed and validated. To this aim, a novel approach for the collection of two tobacco-specific nitrosamines, using silica sorbent cartridges followed by simplified sample preparation and isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry, was applied. |

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