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Laminin-integrin a6b4 interaction activates notch signalling to facilitate bladder cancer development

Laminins are high-molecular weight (400~900 kDa) proteins in extracellular matrix, which serve as major component of the basal lamina, and play a crucial role in promoting tumor cell migration. This study aimed at characterizing the role of laminin in promoting cancer development, and elucidating the mechanism of tumor progression driven by laminin-Notch signalling in bladder cancer. |