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Combatting pain after orthopedic/trauma surgery- perioperative oral extendedrelease tapentadol vs. extended-release oxycodone/naloxone

High post-operative pain scores after “minor” orthopedic/trauma surgery are in part attributed to inadequate prescription of opioid analgesics. Novel concepts aiming to achieve sufficient analgesia while minimizing opioid-related side effects by avoiding fluctuating plasma levels are based on perioperative oral administration of extended-release opioids beginning with the first dose pre-operatively. |