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Distinct epigenetic features of tumorreactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

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Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism of tumor-reactive CD8+ T cells has important therapeutic implications. Yet the DNA methylation status of this T cell subtype has not been elucidated. |

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Distinct epigenetic features of tumorreactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis
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