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Transcription shapes DNA replication initiation to preserve genome integrity

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Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage. |

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Transcription shapes DNA replication initiation to preserve genome integrity

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice