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Overall survival and prognostic factors prostate cancer in Kurdistan Province-Iran: A population-based study (2011-2018)

The population-based survival rate is affected by the quality and effectiveness of health care systems. Overall, the survival of prostate cancer (PC) patients has improved over the past two decades worldwide. This study aimed to determine the overall survival rate and correlate it with the prognostic factors in patients with PC diagnosed in Kurdistan province. | Rasouli et al. BMC Cancer 2021 21 1314 https doi.org 10.1186 s12885-021-09078-8 RESEARCH Open Access Overall survival and prognostic factors prostate cancer in Kurdistan Province-Iran a population-based study 2011-2018 Mohammad Aziz Rasouli1 2 Ghobad Moradi1 2 Bushra Zareie3 Heshmatollah Sofimajidpour1 4 Sima Tozandehjani5 Hedyeh Zafari5 Fatemeh Gholami6 Sonia Shahsavari1 Parisa Hassani5 and Mahshid Mohammadian7 Abstract Background The population-based survival rate is affected by the quality and effectiveness of health care systems. Overall the survival of prostate cancer PC patients has improved over the past two decades worldwide. This study aimed to determine the overall survival rate and correlate it with the prognostic factors in patients with PC diagnosed in Kurdistan province. Methods In a retrospective cohort study 410 PC patients registered in Kurdistan province population-based cancer registry from March 2011 to 2018 were recruited. Kaplan Meier method and log-rank test were used to analyze the overall survival rates of PC patients. A Multivariate Cox regression model was used to determine adjusted hazard ratios for different variables. Results Of 410 patients with PC 263 64.1 died within seven years due to the disease. The 1 3 and 5 years survival rates were 93 64.1 and 40.7 respectively. According to the results of multiple Cox regression the following factors were significantly related to PC survival age at diagnosis 81-years old HR 2.23 95 CI 1.23-4.42 and 71-80 years old was HR 1.26 95 CI 1.12-2.31 occupation employee HR 0.42 95 CI 0.20 0.87 educational level aca- demic HR 0.78 95 CI 0.64 0.91 AJCC stage of disease HR 2.18 95 CI 1.9 3.68 Gleason score 9 HR 7.12 95 CI 5.35 10.28 and Gleason score 8 HR 4.16 95 CI 2.50 6.93 . There was less mortality rate among the patients who had received active care radical prostatectomy radiotherapy combined treatment and orchiectomy had a lower mortality rate than those who received no treatment PRasouli et al. .