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Novel surfactant stabilized PLGA cisplatin nanoparticles for drug delivery applications
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In the current study, cisplatin loaded (Poly(lactic-co-glycolicacid)) (PLGA) stabilized with 4-phenylphenacylbromide based surfactants nanoparticles were developed for drug delivery applications. For the course of this study four new 4-phenylphenacylbromide based compounds abbreviated as PA(C2 )3 , PA(C8 )3 , PAC16 and PAC18 have been synthesized by the reaction of 4-phenylphenacylbromide with various long chain amines. The new surfactants were characterized with 1 H and 13C NMR and FTIR spectroscopy. The critical micelle concentration (CMC) of newly synthesized surfactants are in the range of 0.024–0.091 mM. |