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New antimicrobial biscembrane hydrocarbon and cembranoid diterpenes from the soft coral Sarcophyton trocheliophorum

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The sensitivity of some pathogenic bacteria used as test organisms to the new compounds 1–3 was determined. 1 showed appreciable antimicrobial activity with the diameter of inhibition zones ranging from 11 to 18 mm. 1 was active against the two multidrug resistant bacteria Acinetobacter baumannii and Staphylococcus aureus. Minimal inhibitory concentrations (MICs) of compound 1 were recorded for all the tested bacteria using the fluorescein diacetate method and the recorded MIC values ranged from 4 to 6 µM. |

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