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Fluorescence quenching study of moxifloxacin interaction with calf thymus DNA

Moxifloxacin (MOX) is a fourth-generation synthetic fluoroquinolone antibacterial agent with many important therapeutic properties. Fluorescence quenching was used to study the interaction of MOX with calf thymus DNA (ctDNA) in aqueous solution. As the most common genetic material of various biosomes in nature, deoxyribonucleic acid (DNA) plays a key role in different kinds of vital processes including gene expression, mutagenesis, cell death, etc. An increasing number of studies have suggested that there is an essential linkage between environmental factors (chemical drugs, nuclear radiations, etc.) and genetic damage. |