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Oxime-containing acetylcholinesterase reactivators and their complexes with Pd(II) and Pt(II) ions: Recent developments

The ability of oxime-containing acetylcholinesterase reactivators BT-07 (K005), BT-08 (K033), BT-07-4M (K074), and obidoxime (H2LX2, X = Cl−, Br−) to bind palladium(II) or platinum(II) cations was evaluated in aqueous solutions (pH 7.4) at metal-to-ligand molar ratio varying from 1:10 to 10:1. Spectral changes were monitored within a week after mixing the reagents in the range from 220 nm to 500 nm. Results showed that depending on chemical structure and reaction time, oximes form two complex species of composition, [MHL]3+ or [M2L]4+ (M = Pd(II), Pt(II)). It was also found that complexation of platinum(II) ions proceeds slower as compared to palladium(II). |