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Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

Lanthipeptides belong to the ribosomally synthesized and post-translationally modified peptide group of natural products and have a variety of biological activities ranging from antibiotics to antinociceptives. These peptides are cyclized through thioether crosslinks and can bear other secondary post-translational modifications. |