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A genome-scale CRISPR interference guide library enables comprehensive phenotypic profiling in yeast

CRISPR/Cas9-mediated transcriptional interference (CRISPRi) enables programmable gene knockdown, yielding loss-of-function phenotypes for nearly any gene. Effective, inducible CRISPRi has been demonstrated in budding yeast, and genome-scale guide libraries enable systematic, genome-wide genetic analysis. |