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Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells

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Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulation of its expression is critical to understand its roles in renal diseases. Indeed, reduced expression was observed in various renal disease. |

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Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells
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