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In silico probing Ca2+ and Zn2+ permeable transmembrane 4Aβ1−42 barrel
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Alzheimer’s disease (AD) is known as one of the most popular forms of dementia affecting numerous people worldwide. The Amyloid beta (Aβ) peptides form oligomeric conformations that cause the intracellular Ca2+ and Zn2+ abnormality leading to the death of neuron cells. The failure of AD therapy targeting Aβ oligomers probably caused by misunderstanding the ions transport through transmembrane Aβ (tmAβ) ion-like channel since Aβ oligomers transiently exist in a mixture environment involving various order of Aβ oligomers. The high-resolution of tmAβ peptides are thus unavailable until the date. |