tailieunhanh - In silico homology modeling and epitope prediction of outer membrane protein omp W, a potential vaccine candidate against Edwardsiella tarda

Edwardsiella tarda is a Gram negative bacterium with a wide host range, mainly affecting fishes. It is a dreaded pathogen of cat fish culture. The presence of large number of serotypes of the pathogen makes the vaccine production against the pathogen a difficult task. Here in this study the suitability of outer membrane protein W (OMP W) as a vaccine candidate against E. tarda was investigated. OMPs has the characteristics of localization in the outer membranes of Gram negative bacteria, which make them easily accessible to the host antibody there by triggering an antigen antibody reaction in the host body. The 3D structure of the protein was constructed using homology modeling, the quality of the model was evaluated and finally the factors for a biological molecule to be considered as a vaccine candidate were being checked for the OMP. | In silico homology modeling and epitope prediction of outer membrane protein omp W a potential vaccine candidate against Edwardsiella tarda

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