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Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: Analysis of two Phase I, randomised, double-blind, placebo-controlled studies

AZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV1 was observed following inhalation of nebulised doses of AZD9164 in citrate buffer. |